Multicancer early detection tests (MCED)

How it works

In order to become cancerous, a cell first experiences one or more changes in its DNA. This is the genetic information that controls how the cell behaves. Once these DNA changes have occurred, then the cell may begin to divide out of control, which causes it to become cancerous. A blood test can look for abnormal DNA fragments (also known as circulating tumor DNA or ctDNA) in the blood that are associated with cancer. This is sometimes known as a “liquid biopsy,” because it checks for cancer cells in much the same way that a biopsy does. However, instead of taking out a small piece of tissue surgically, the liquid biopsy uses a blood test. DNA fragments are released from cancer cells into the bloodstream, making it possible to detect many different types of cancer with a single blood test.

There are 4 different options of LucenceINSIGHT test. Here’s what each option covers:

The LucenceINSIGHT 5 test checks for 5 different types of cancer, including:

• Thyroid cancer

• Lung cancer

• Liver cancer

• Pancreatic cancer

• Colorectal cancer

The LucenceINSIGHT 7 test is for women, and checks for 7 different types of cancer, including:

• Thyroid cancer

• Lung cancer

• Liver cancer

• Pancreatic cancer

• Colorectal cancer

• Breast cancer

• Ovarian cancer

The LucenceINSIGHT 12 test checks for 12 different types of cancer, including:

• Breast cancer

• Lung cancer (both small cell and non small cell lung cancers)

• Lung neuroendocrine tumors

• Nasopharyngeal cancer

• Liver cancer

• Biliary tract cancer

• Cervical cancer

• Gastrointestinal stromal tumor (GIST)

• Pancreatic cancer

• Colorectal cancer

• Prostate cancer

The LucenceINSIGHT 50 checks for 50 different types of cancer. In addition to the cancers listed above, this test also checks for:

• Thyroid cancer

• Esophageal cancer

• Eye cancer

• Oropharyngeal cancer

• Laryngeal cancer

• Salivary gland cancer

• Non Hodgkin lymphoma

• Hairy cell leukemia

• Acute myeloid leukemia

• Mast cell tumor

• Myeloproliferative neoplasms

• Myeloma

• Kidney cancer

• Adult Wilms tumor

• Adrenal gland cancer

• Stomach cancer

• Stomach neuroendocrine tumors

• Small intestine cancer

• Colorectal neuroendocrine tumors

• Bladder cancer

• Endometrial cancer

• Ovarian cancer

• Ovarian germ cell and stromal tumors

• Vulvar cancer

• Penile cancer

• Testis cancer

• Soft tissue cancer

• Bone cancer

• Skin cancer

Accuracy

Lucence INSIGHT screens for the risk of cancer with a sensitivity of 80.9%. This means that it has an 80.9% chance to correctly detect cases of the particular disease in question. It also has a specificity of 99%, which means that it can correctly identify when a person being tested does not have the disease 99% of the time.